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SAM-e (S-adenosyl-L-methionine) is a natural occurring substance
that exists in the cells of the human body. It is considered to be
metabolite of the essential amino acid L-methionine. SAM-e is also
known by many as ademetionine, S-adenosylmethione, SAM, SAMe, and
SAM-e.
Among the numerous supplements marketed, SAM-e is one
of the few worthy of attention from researchers and consumers. SAM-e
is not an herb, vitamin, hormone, or dietary nutrient; it is a
synthetic form of a chemical that is naturally produced by the human
body. SAM-e is essential to a large variety (40 or more) of chemical
processes, including cell maintenance, nerve function, and
influences both human emotions and moods.
SAM-e supplements
are marketed for use in connection with a variety of conditions
including arthritis (osteoarthritis), depression, fybromyalgia, and
liver disease. Many individuals maintain that SAM-e is as effective
for pain relief as aspirin, but does not produce the same side
effects such as stomach irritation. It is also believed by many to
be more effective for relieveing depression than many common
anti-depressants. Since SAM-e is not regulated by the FDA, it does
not require a doctor's prescription. However, in other regions such
as Europe, SAM-e is sold as a prescription drug for treating
depression, arthritis, and liver disease.
SAM-e is normally
produced in the liver from the amino acid methionine found in most
healthy diets. Both folic acid and vitamin B12 are required for the
synthesis of SAM-e, and deficiencies of either of these vitamins may
result in low concentrations of SAM-e in the central nervous system.
Lower than normal levels of SAM-e have been detected in individuals
with liver cirrhosis, heart disease, Alzheimer’s disease, and
depression.
While SAM-e may be a very effective supplement
for use in connection with a number of health conditions, it does
require long-term daily usage.
Possible Side Effects
of SAM-e
Most people that are taking SAM-e do not
report any side effects. A few people taking high doses have
reported headache, stomach upset, insomnia, and dizziness. If you
are suffering from severe depression, you should seek advice from a
doctor before supplementing with SAM-e. It has also been suggested
that individuals with bipolar disorder should avoid SAM-e since it
may bring on manic episodes.
Dosage and
Administration of SAM-e
How much is usually taken?
Most healthy people do not need to supplement with SAM-e.
Researchers working with people suffering from a variety of
conditions have employed the following amounts:
- Depression, 1,600 mg per day
- Osteoarthritis, 800–1,200 mg per day
- Fibromyalgia, 800 mg per day
- Liver Cirrhosis, 1,200 mg per day
- Migraine, 800 mg per day
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