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Pyruvate is a form of an organic acid called pyruvic acid.
Pyruvate is involved in energy synthesis in most living organisms.
It is not considered an essential nutrient since it can be produced
in the cells of the body. Pyruvate, however, is consumed in the
daily diet. Most individuals consume between 100 and milligrams to 2
grams per day. Pyruvate can be found in high concentration in a few
fruits (apples) and vegetables, as well as in dark beer and red
wine.
It is believed that pyruvate may aid weight loss
efforts. One study showed that 22–44 grams per day of pyruvate
enhanced weight loss and resulted in a greater reduction of body fat
in overweight adults when combined with a low-fat diet. Similar
studies that employed 6–10 grams of pyruvate per day combined with
an exercise program also lost weight. A few clinical studies suggest
that pyruvate supplementation leads to weight loss by increasing the
resting metabolic rate.
There is also the suggestion in
current research that it might help some obese individuals lower
their blood pressure and it may favorably modify lipid profiles. It
also appears to enhance exercise endurance in some and may be
protective in others with cardiac ischemia. It has been suggested
that pyruvate might even have an ability to reduce insulin
resistance.
Preliminary research suggests that pyruvate is an
antioxidant,
inhibiting the production of harmful free
radicals.
Dosage and
Administration
Those using pyruvate to loose weight
have been known to take at least 30 grams per day. However, the most
current research suggests a dose of 5 to 6 grams daily for a
possible bariatric action or for athletic use.
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