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Para-aminobenzoic acid or PABA is a non-protein amino acid that
is widely distributed in nature. It is sometimes referred to as
vitamin Bx (Vitamin B Complex), but it is neither a vitamin nor an
essential nutrient for humans. PABA is an intermediate in the
synthesis of folic acid in bacteria. The sulfonamide antibiotics are
structurally similar to PABA and interfere with the synthesis of
nucleic acids in sensitive micro-organisms by blocking the
conversion of PABA to the co-enzyme dihydrofolic acid, a reduced
form of folic acid. In humans, dihydrofolic acid is obtained from
dietary folic acid.
Suggested Benefits of
PABA
PABA is most commonly known for its ability to
protect the skin from the harmful rays of the sun when used
topically. It has also been suggested that PABA may also prevent or
even reverse the accumulation of abnormal fibrous tissue in the
body.
Pharmaceutical doses of PABA are indicated for
Peyronie's disease, scleroderma, morphea, and linear scleroderma.
There is less evidence to indicate it for pemphigus and
dermatomyositis. Claims that it can halt hair loss and restore color
to graying hair are entirely anecdotal.
While other effects
of PABA supplementation have been reported, they have not been
substantiated by any meaningful evidence.
Recommended
Dosage
In addition to PABA, the potassium salt of
PABA called POTABA is available on prescription. POTABA is indicated
for Peyronie's Disease and scleroderma.
The recommended dose
for use in connection with Peyronie's disease and scleroderma is
high and should only be used under the supervision of a doctor. The
dose used for these disorders is 12 grams daily taken in four to six
divided doses with meals. The tablets must be dissolved in plenty of
liquid to prevent gastrointestinal upset.
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