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Eicosapentaenoic acid (EPA) is omega-3 fatty acid that is used in
cellular processes within the body. Unfortunately, most people's
diets today do not include substantial amounts of omega-3 fatty
acids. The main dietary sources of EPA are cold water fish such as
salmon. Consequently, fish oil supplements are a good source of EPA.
Increasing the amount of EPA in the body has shown to be beneficial
for preventing or dealing with high blood pressure, coronary heart
disease, and inflammatory disorders such as rheumatoid
arthritis.
Medical Indications and
Benefits
- Cardiovascular Health - Clinical studies indicate that
omega-3 fatty acids may help to improve cardiovascular health and
may prevent the accumulation of plaque (cholesterol and fat) on
the walls of the arteries. Fish oil supplementation may help
reduce high blood pressure in people with diabetes.
- Autoimmune Diseases - The omega-3 fatty acids,
including EPA, may modify the immune response and help when used
in connection with autoimmune diseases such as rheumatoid
arthritis.
- Growth and Development - Nutrition experts have issued
recommendations for appropriate intake of each type of omega-3
fatty acid in infant formulas and diets. According to these
recommendations, intake of EPA for infants on formula diets should
be less than 0.1%.
- Additional Benefits - Omega-3 fatty acids, including
those found in EPA, may also have positive effects on lung and
kidney diseases, Type II diabetes, obesity, ulcerative colitis,
Crohn's disease, burns, anorexia nervosa, osteoporosis,
osteoarthritis, attention deficit/hyperactivity disorder, and
early stages of colorectal cancer.
Dosage
EPA is typically available
in fish oil in combination with DHA. The usual ratio of EPA to DHA
in these preparations is about 1.5. Fish oil preparations are
available with higher ratios up to about 3. There is an ethyl ester
form of EPA. The adequate daily intake of EPA for adults should be
at least 220 mg/day. Fish oil supplements: 3,000 to 4,000 mg
standardized fish oils per day. This amount corresponds to 2 to 3
servings of fatty fish per week.
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