|
Pectin is a soluble fiber that is found in most plants, but is
most concentrated in citrus fruits and apples. Pectin is obtained
from the citrus peels of fruits and apple pulp. Pectin obtained from
citrus peels is referred to as citrus pectin. For medicinal use,
pectin is used in combination with the clay kaolin (hydrated
aluminum silicate) for the management of diarrhea. Pectin is also
marketed as a nutritional supplement for the management of elevated
cholesterol.
D-Galacturonic acid is the principal
monosaccharide compoud that composes pectin. Some neutral sugars are
also present in the substance. The D-galacturonic acid residues are
linked together by alpha-1, 4 glycosidic linkages. There are
different types of pectin. Pectin in which more than 50% of the
galacturonic acid residues are esterified is called high methoxyl or
HM pectin. Pectin in which less than 50% of the galacturonic acid
residues are esterified is called low methoxy or LM pectin. Pectin
is a nondigestible polysaccharide. So-called modified citrus pectin
is pectin that has been hydrolyzed and otherwise modified to make it
more digestible and absorbable.
Medical
Indications
Pectin appears to produce
hypocholesterolemic actions and may be antiatherogenic to some
individuals. It is used in some multi-ingredient preparations for
the treatment of constipation and diarrhea. Claims that it is an
effective antiobesity agent are unsubstantiated. There are studies
suggesting that pectin might have some anticancer
effects.
Dosage and
Administration
There are no typical doses of pectin
supplements. Doses of 10 to 15 grams daily have been used in studies
showing cholesterol-lowering effects in hypercholesterolemic
individuals. Pectin supplements should be used with plenty of fluid.
|