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Calcium D-Glucarage (the calcium salt of D-glucaric acid) is a
relatively common nutrient found in many fruits and vegetables. Many
believe that this nutrient aids the body in the elimination of many
harmful substances and to lower abnormally high levels of estrogen.
Both these effects may help to protect against the development of
breast, colon, and prostate cancers.
Some studies have
indicated that Calcium D-glucarate may help to inhibit
beta-glucuronidase, an enzyme found in certain bacteria that reside
in the intestines. One way that toxic chemicals as well as hormones
such as estrogen are eliminated from the body is by attaching
glucuronic acid to them in the liver and then excreting them
together in as substance called bile. Beta-glucuronidase is a
bacterial enzyme that uncouples (breaks) the bond between the
excreted compound and glucuronic acid. When beta-glucuronidase
breaks the bond, the hormone or toxic chemical that is released is
available to be reabsorbed into the body instead of being excreted.
An elevated beta-glucuronidase activity is associated with an
increased risk for various cancers, particularly hormone-dependent
cancers like breast, prostate, and colon cancers.
Based on
this reasoning many professional believe that Calcium D-Glucarate
may in fact aid in the prevention of different deadly
cancers.
Dosage
Calcium d-glucarate
(as calcium salt - glucaric acid) is available in capsules and
tablets. Although we know of no recommendations for dosing that are
available in scientific literature, a commonly suggested dose for
cancer prevention is 200 mg once a day or twice a day. To treat
existing cancers, daily doses of 1,200 mg or higher reportedly have
been taken without apparent side effects.
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